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Statistical analysis of samples from the generalized exponential distribution
Votavová, Helena ; Popela, Pavel (oponent) ; Michálek, Jaroslav (vedoucí práce)
Thesis deals with generalized exponential distribution as an alternative distribution to Weibull and log-normal distributions. At first, properties of the generalized exponential distribution are presented, followed by the methods of parameter estimation. Separate chapter describes goodness of fit tests. Second part of the thesis deals with censored samples. Demonstrative examples of censoring on exponential distribution are presented. Moreover the type I left censored case on generalized exponential distribution, which has not been studied before, is elaborated at the end of the chapter. Simulations for this particular case of censoring are presented and studied in detail. EM algorithm is developed and its efficiency is compared to the maximum likelihood method. The derived theory is then applied on set of environmental data.
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Statistical analysis of samples from the generalized exponential distribution
Votavová, Helena ; Popela, Pavel (oponent) ; Michálek, Jaroslav (vedoucí práce)
Thesis deals with generalized exponential distribution as an alternative distribution to Weibull and log-normal distributions. At first, properties of the generalized exponential distribution are presented, followed by the methods of parameter estimation. Separate chapter describes goodness of fit tests. Second part of the thesis deals with censored samples. Demonstrative examples of censoring on exponential distribution are presented. Moreover the type I left censored case on generalized exponential distribution, which has not been studied before, is elaborated at the end of the chapter. Simulations for this particular case of censoring are presented and studied in detail. EM algorithm is developed and its efficiency is compared to the maximum likelihood method. The derived theory is then applied on set of environmental data.
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On Two Methods for the Parameter Estimation Problem with Spatio-Temporal FRAP Data
Papáček, Š. ; Jablonský, J. ; Matonoha, Ctirad
FRAP (Fluorescence Recovery After Photobleaching) is a measurement technique for determination of the mobility of fluorescent molecules (presumably due to the diffusion process) within the living cells. While the experimental setup and protocol are usually fixed, the method used for the model parameter estimation, i.e. the data processing step, is not well established. In order to enhance the quantitative analysis of experimental (noisy) FRAP data, we firstly formulate the inverse problem of model parameter estimation and then we focus on how the different methods of data pre- processing influence the confidence interval of the estimated parameters, namely the diffusion constant $p$. Finally, we present a preliminary study of two methods for the computation of a least-squares estimate $\hat{p}$ and its confidence interval.
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